|
KMID : 0377519960210020139
|
|
Chung-Ang Journal of Medicine
1996 Volume.21 No. 2 p.139 ~ p.150
|
|
|
Apoptotic Changes of Neurons in Hippocampal Formation of Neonatal Rat Brains
|
|
|
|
|
Abstract
|
|
|
For the investigation of the apoptotic changes of dentate granule cells in neonatal rat brains, the neurons exhibiting chromatic clumping and positive immunoreaction were observed by hematoxylin and eosin staining and immunohistochemistry light
microscopically.
1. Numerous dentate neurons exhibited regressions without necrotic change, which was a process of apoptosis.
2. Apoptotic neurons in dentate gyrus were present in upper and lower blades and had the increasing gradient of regression toward the inner in upper blade and outer parts in lower ones.
3. Apoptotic neurons in dentate gyrus had increasing gradient of regression from molecular to polymorphic layers, and ganule cells exhibited more regression in 6 days than in 4 days.
In summary, numerous dentate granule cells in normal development exhibited apoptotic process with relatively constant increasing gradient.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|